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by seph

Diabetes Complications Include Painful Gallbladder Stones, Studies Affirm

2:01 pm in Weight Problems by seph

Type 2 diabetes has been held responsible for numerous complications ranging from heart diseases, kidney failures, eye troubles, and even the agonizing gallbladder stones, according to online reports. It was reported in the Libyan Journal of Medicine, based on a study involving patients experiencing diabetes, that over 40 percent suffer gallbladder disorders compared to those without diabetes. Gallstone disease has become a very prevalent disease, with incidence rising proportionately with increase in the number of diabetes cases.


Without an accepted reason for the connection between diabetes and gallbladder problems, only possible explanations have been suggested by medical experts. Obesity, which usually characterizes the diabetes patient, is one reason given since this is also a risk factor for gallstone problems. Experts have suggested that high levels of triglycerides, a type of fat present in diabetics, may play a big role in the formation of gallstones.


Experts have suggested that the long term effect of diabetes which is autonomic neuropathy or damage to the involuntary nerves may also be a reason behind this. It has been thought that the bile which is stored in the gallbladder may not be efficiently released due to defects in the nerves which regulate the movement of the bowels and gallbladder, causing it to accumulate resulting to the formation of gallstones.


Considered to be the latest theory is the presence of a protein that is associated with diabetes, according to the findings of a recent research made on insulin-resistant animals. This protein, which has been named as FOXO1, is thought to increase the quantity of cholesterol that enters the bile which may cause an imbalance resulting to the formation of gallbladder stones.


Undue pressure may be created resulting to the appearance of symptoms when these gallstones become embedded in the neck of the gallbladder or in the bile ducts. A gallbladder attack is commonly indicated by a sudden pain in the upper right portion of the abdomen which may last for a few minutes to several hours. Especially after a meal, abdominal pain may also be experienced in the middle right area.


Fever, nausea, vomiting, and loss of appetite may be experienced if there is an infection or inflammation of the gallbladder. A person may have dark urine, light-colored stools, and yellowing of the skin and the whites of the eyes (jaundice), accompanied by fever and chills, when a gallstone blocks the common bile duct.


Experts encourage patients to follow the usual management of diet, exercise, and reduction of weight, especially if we consider that this disease may cause problems to a diabetic-stricken person since gallbladder removal, which is the usual treatment option, may pose additional risks. This problem may be compounded when complications arise due to the use of certain medications such as the Byetta and similar drugs, as alleged by numerous complainants who have filed Byetta lawsuits. For details and updates, you may refer to



by seph

FDA, Doctors See No Link Between Pancreatic Cancer, Byetta-type Drugs

2:32 am in Weight Problems by seph

Medical authorities see no increased risk between pancreatic cancer and Byetta-type pharmaceutical formulations, reports, mentioning initial reactions from certain doctors attending the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) conference. Reactions from these doctors were given after listening to presentations of medical experts, among them Dr. Peter Butler who conducted a study linking these drugs to pancreatic cancer. The evaluation of various studies was hoped to allow concerned agencies to resolve the issue particularly for the Food and Drug Administration (FDA) and European Medicines Agency (EMA) who have been getting bad raps from the British Medical Journal on the handling of the Byetta and pancreatic cancer controversy.


There were many questions raised and there was much skepticism regarding the risk of cancer of the pancreas, according to Dr. Joseph Whitcomb, an expert of the pancreas and who acted as co-chairman of the NIDDK meeting. Dr. John Buse of the University of North Carolina School of Medicine also stated that no signal of pancreatic cancer can be detected based on the data from companies and other investigators. It would seem that the presentations of medical experts connected with drug manufacturers were given more credence by these doctors over the study conducted by Dr. Peter Butler.



Three points were raised by Dr. Whitcomb in assailing the clinical trials performed by the team of Dr. Butler. Pointed out as the first concern was the ages of the subjects for both the control group who were in their 30s and the patients who were found to have pancreatic cancer who were in their 50s. According to the doctor, the critical issue was in defining the appropriate control group and when the right control group is used, there is no evidence of increased risk.


The lesion found by Dr. Butler, the alpha-hyperplasia, is the wrong kind of cancer was asserted by Dr. Whitcomb. Pancreatic cancer is associated with glucagonoma, which was never discovered, and not hyperplasia.


The use of the weight of the pancreas in calculating hyperplasia was another point raised by the doctor. The results of the study may have been affected by this since, according to Dr. Whitcomb, the pancreas of those with diabetes and in the elderly people tends to shrink.  


On the other hand, both doctors gave weight to the claims of Dr. Alan Moses, the global chief medical officer of Novo Noridisk and Dr. Sam Enger, the medical expert from Merck. An analysis based on a five-year study was presented by Dr. Moses which showed that the risk of pancreatic cancer was 0.7 compared to other diabetes drugs such as the widely-used metformin. In the study conducted by Merck using 14,000 patients from 25 randomized clinical trials, it was concluded that there was no increased risk of pancreatic cancer with use of their medications.


Based on their reactions, even the Food and Drug Administration (FDA) would seem to agree with the position of both doctors which suggests that no signal of pancreatic cancer can be detected. This was based on its own evaluation using different studies and independent of those conducted by pharmaceutical companies. Vigilant monitoring of the issue as well as supporting long-term studies on the subject have been assured by the FDA perhaps to assuage everyone concerned and to be on the safe side.


It is unfortunate that the side of Dr. Butler was not aired to answer these questions raised by the two doctors who incidentally have relationships with drug manufacturers. Reactions of the two doctors on the recommendations of the Institute of Safe Medication Practices (ISMP) and on the results of other studies such as the one conducted by Dr. Singh of the John Hopkins University would also be very welcomed by the millions of people affected with diabetes.



by seph

Understanding Why Diabetes Affects Your Sex Life

2:02 am in Weight Problems by seph

Diabetes-associated damages run in many directions, from the nerves at one point to the blood vessels, sugar production capacity, and emotion controls, in another. Based on various clinical studies, medical experts have long acknowledged that this medical condition may impact significantly on a man’s sexual health. Long before any long-term complications or damages may surface, a person suffering from diabetes may encounter sexual problems like erectile dysfunction or a decline in sexual desire.


The following are the causes of this complication which may affect over 50 percent of men suffering from diabetes:



Damage to Nerves

Due to the damage caused by your condition to the nerves, signals from the brain consisting of sexual desire may not be sent properly to your body and sexual organ. Responsible for the nerve damage is the high level of blood sugar which results to the failure to provide the necessary oxygen and nutrients thereby affecting the proper functioning of the cells. Although you may be emotional aroused, your sexual organ will not be able to receive any sensation and therefore no response provided.


Blood Vessel Damage

Blood vessels may also be damaged by a high level of blood sugar which may restrict the flow of blood due to the narrowing or hardening of the blood vessels. Inadequate blood going to the penis may result to the inability to achieve or sustain erection since a man’s erection is brought about by the flow of blood.


Lack of Nitric Oxide

The inability to produce nitric oxide is another effect of poor blood sugar. This chemical, which is released in the penis, is very vital in providing erections for the male. Nitric oxide is very vital in providing erections for the male when released in the penis. There might not be enough blood to close off the veins since this may be prevented by the lack of nitric oxide. The blood may then flow back resulting to making the penis flaccid when the quantity of blood required to sustain an erection is not maintained.


Mental or Emotional Factors

Failure to achieve erection may have severe implications on your mental condition. You may become impotent when your fear of failure makes an impact on your psyche. Body chemicals which may dampen sexual performance may be produced when a person is under stress.


Distressing this might be, you should not be worried since there are some things you can do to address this problem What is important is to control your blood sugar level through lifestyle changes such as following the proper diet, engaging in physical activities, quitting smoking, and maintaining the ideal body weight.


Your doctor may also prescribe medications for the management of your diabetes condition. You should take an active role when prescribed with medications by knowing the benefits and side effects of these medicines. Diabetes medicines such as Byetta and other brands under the same class have been alleged by patients to cause severe complications. These complaints have resulted to litigations such as the Byetta lawsuits. You may visit for more information regarding this matter.



by seph

Results Of Studies On Byetta Complications Alarm FDA

7:32 pm in Weight Problems by seph


Using the new findings of academic researchers on the possible risks associated with the use of a class of drugs called incretin, which includes the Byetta injectable, the Food and Drug Administration (FDA) will conduct a comprehensive evaluation, according to their statement released in March this year. These researches included one which was undertaken very recently and determined that the continued use of Byetta may increase the risk of thyroid cancer.


Additional data such as details of the study and tissue samples have already been requested by the agency which it may use for further evaluation. Forum for this evaluation will be the  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and National Cancer Institute’s (NCI) Workshop which the FDA will participate this coming June. The agency is hoping to come up with conclusions and recommendations regarding this issue after sharing and gathering relevant inputs during the workshop.



Concerned sectors are hoping that the FDA will be able to come up with more decisive actions to address this serious and growing problem. Confronted with the same issue in previous years, the FDA’s actions consisted of issuing notices to healthcare providers and ordering manufacturers to amend their labels by indicating possible risks involved in the use of these medications. Adverse reports at that time indicated that the use of Byetta was associated with the increase in complications affecting the pancreas and other important organs.


More serious problems resulting from the continued use of Byetta medications have been pointed out by the latest studies of these different research groups. The Institute for Safe Medication Practices, using the adverse reports provided by the FDA, reported that in a span of one year, over 105 cases of pancreatic cancer were observed as compared to only two patients who were using a different type of diabetes medication. An earlier research made by the University of California in Los Angeles where it reported an increase in pre-cancerous cellular changes by as much as 40 percent is supported by this latest study by ISMP.


The continued use of Byetta and other drugs in the same class may increase the risk of a patient in developing thyroid cancer, according to a report in the medical journal Gastroenterology, based on the study conducted by Dr. Peter Butler. The same negative findings, based on a different study, were also reported in the GI & Hepatology News, which is the official newsletter of the American Gastroenterological Association (AGA).